Tag: alcohol

Posted in History & Literature

Martini

Posted on by Jinavie

A martini is a classic cocktail made from 3~4 parts gin and 1 part dry vermouth. It is then stirred in a mixing glass with ice cubes, strained then garnished with a green olive or a twist of lemon peel. It is most famous for being the drink of choice of James Bond – the most famous spy in the fictional world. Bond frequently orders a vodka martini (vodka instead of gin) and is famous for asking it to be “shaken, not stirred”.

The reason for his preference has never been given in the novels, but that did not stop Bond enthusiasts, martini connoisseurs and even scientists from investigating why Bond may have preferred a shaken martini as opposed to a stirred one.

When you shake a drink with ice, it becomes colder than when it is stirred for the same amount of time. This may be the main reason Bond liked a shaken martini (also called a Bradford), as a martini is typically served as cold as possible.

However, shaking a cocktail has some consequences. The vigorous shaking will introduce more air into the cocktail (“bruising” the drink), which makes it taste sharper and more bitter. The bubbles also makes the drink cloudier and have a different texture. Furthermore, shaking causes the ice to chip (as opposed to the much gentler stirring), which serves to make the drink cloudier and more diluted. Therefore, the shaking essentially makes the drink weaker.

An alternative theory as to why Bond asked for his martini to be shaken is that vodka was often made from potato more than grain prior to the 1960s. Potato vodka has an oilier texture and shaking helps disperse the oiliness and improve the taste.

A biochemical analysis of stirred versus shaken martinis reveal that shaking causes more hydrogen peroxide to break down, meaning a shaken martini leaves half the peroxide left in a stirred martini. The reduced hydrogen peroxide content results in more antioxidants, which has health benefits such as reducing the risk of cardiovascular disease, cataracts and stroke.

Posted in Psychology & Medicine

Viscera: Liver

Posted on by Jinavie

(Learn more about the organs of the human bodies in other posts in the Viscera series here: https://jineralknowledge.com/tag/viscera/?order=asc)

The liver is the second largest organ (next to the skin) in the human body, weighing about 1.4~1.6kg. It is found tucked under the right side of the ribcage, underneath the 5th to 10th rib in height and almost spanning the entire width of the trunk. When enlarged, the liver grows downward and can be felt in an abdominal exam (sometimes it is so large that it covers most of the abdomen).

It is a vital organ with many life-sustaining functions (hence “liver”) such as building various proteins, breaking down toxins, storing sugars in the form of glycogen, decomposing red blood cells and producing bile. The liver metabolises (breaks down) a large proportion of medications and drugs as it treats them as “toxins”. For example, the enzyme alcohol dehydrogenase breaks down alcohols into acetaldehyde, which causes hangovers and liver damage. Many Asians have a variant of this enzyme that is extremely efficient, causing a massive build-up of acetaldehyde when they drink alcohol. This is responsible for the so-called “Asian flush”.

Liver disease is associated a myriad of symptoms. The classic sign of jaundice (yellow skin and whites of eyes) is caused by obstruction of bile flow. Because of its location, pain in the right upper quadrant of the abdomen is commonly seen. As the liver is involved in synthesising various proteins, signs such as ascites (fluid in the abdomen) or bleeding may occur when the liver is damaged. A syndrome called portal hypertension is commonly seen in chronic liver disease such as cirrhosis as a major vein to the liver is blocked. This can cause an enlarged spleen, oesophageal varices that can bleed, ascites and prominent veins radiating from the belly button (caput medusae).

An interesting property of the liver is that it can regenerate at an amazing rate. A liver will regenerate to its original size even when a half of it is cut out (this is how live donor liver transplants work). What is more interesting is that the ancient Greeks probably knew of this fact as well. In Greek mythology, the gods punish Prometheus for bringing fire to humans by chaining him to a mountain and commanding an eagle to peck out his liver. The liver would then regenerate overnight and the eagle would return every morning to eviscerate him, causing him eternal anguish.

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Posted in Science & Nature

Wine Aging

Posted on by Jinavie

One of the (many) defining features of a “great wine” is the aging of the wine. The complex chemical reactions between the wine’s sugars, acids and tannins can produce a much deeper, sophisticated aroma and taste that stays in the mouth for longer. For example, the tannins break down to give a softer mouthfeel. Acids and alcohols combine in the wine to form esters – chemical compounds that produce very unique smells. This also reduces the perceived acidic taste of the wine, making it less sour. The longer the wine has aged, the more of these chemical reactions occurs and the wine typically improves in quality.

Of course, the problem with wine of excellent quality is the price and the time required to age the wine. Is there any way to artificially “age” wine? The solution lies in something that sounds like science fiction: irradiating the wine.

If you expose a bottle of wine to radiation (about 500 rads) for an hour, it can greatly improve its maturity. In a simple experiment, blind-tasted sommeliers could not believe that the two glasses of wine – one before irradiation and one after – were exactly the same. In fact, they valued the irradiated wine at almost five times the market price of the original bottle. The reason for this is that radiation accelerates the esterification process of the acids in the wine, producing a much deeper and smoother taste.
There are also other experiments that have shown that magnetism, ultra-sonic waves and high-voltage electricity can all be used to artificially age wine.

Although radiation does not turn people into superheroes, it turns out it can for wine.

Posted in History & Literature

Honeymoon

Posted on by Jinavie

It is customary for a newlywed couple to embark on a romantic vacation to celebrate their marriage. This is known as a honeymoon. The word originates from the Scandinavian region – the home of the Vikings. The Vikings had a tradition (as did many other European cultures) where a newlywed couple would drink mead for a whole month. The reason being, it was believed that mead was good for stamina and would facilitate fertilisation. Ergo, the honeymoon’s original purpose was to provide a time for the couple to make a child. Ironically, alcohol has the effect of inhibiting not only the cerebral cortex (causing sexual disinhibition), but also testosterone, leading to erectile dysfunction. Thus, drinking like the Vikings on your honeymoon would be very counterintuitive if you are thinking of making a child (or just love). Furthermore, it may endanger your marriage right from the start.

Whatever the origin of the word, a honeymoon is indubitably the sweetest time for a couple as they celebrate their promise for eternal love and look forward to a future they will build together. Perhaps the true meaning of “honeymoon” is a metaphor for the sweetness of a newly developing romance.

Posted in History & Literature

Mary Celeste

Posted on by Jinavie

In 1872, a ship by the name of Mary Celeste was spotted off the Azores in the Atlantic Ocean – completely intact and undisturbed aside from its missing crew. Not a single person, alive or dead, could be found, despite everyone’s personal belongings still sitting undisturbed where they had been left. Even little things such as valuables and piano music were right where they should have been. It was as if its crew had simply evaporated. There were no signs of a struggle and no cargo was missing. To this day, the case of the disappearing crew of the merchant ship Mary Celeste is one of the most famous maritime mysteries in history.

So what happened to the ship’s crew? Historians have been trying to figure out their fate for decades, but the question was finally solved by scientists. One fact that is known about the Mary Celeste is that of its cargo of 1701 barrels of alcohol, 9 were empty. Although an obvious answer is that the sailors went overboard with a party, the truth is even more spectacular. In 2006, Dr. Andrea Sella, a professor of chemistry at University College London, created a replica of the Mary Celeste’s hold to find out how to create an explosion without leaving a trace of fire. He simulated a leak of the ship’s nine barrels of alcohol and found that once the vapour was ignited, say by a pipe or a spark, it created a pressure-wave type of explosion. There was a spectacular wave of flame but, behind it was relatively cool air. No soot was left behind and there was no burning or scorching.

Ergo, the mystery of the Mary Celeste is most likely as follows: there was a leak of the alcohol, the vapour of which fuelled a massive ghost explosion that swept through the ship. The sailors, completely unscathed but utterly horrified, would have piled into the ship’s lifeboat without any useful things like food or water, eventually sinking or dying of thirst and exposure. The Mary Celeste would have still looked perfectly fine as it drifted the vast ocean, all by itself.

Posted in Psychology & Medicine

Pleasure Centre

Posted on by Jinavie

During the 1950’s when the field of neuroscience was making many research breakthroughs, a fascinating fact was discovered. Scientists had located the specific part of the brain responsible for feeling pleasure. In 1954, two Canadian neuroscientists named James Olds and Peter Milner were undertaking research to find the association between electrical stimulation of the brain and sensation in rodents. During their research, they found that if they stimulated a certain part of the brain, the rats would interpret the signal as pleasure. Based on this, they inserted electrodes into the rats’ limbic system (the part responsible for emotions) and connected it to a lever in the cage. Thus, they had devised a device that allowed the rat to feel pleasure by stimulating its own brain with the press of a lever. The results were astounding. The rat furiously pumped at the lever, forgetting to eat or sleep, until it ultimately died of exhaustion (over 26 hours, the rat pressed the lever 50,000 times).

Pleasure is not the same as happiness. Happiness awards us with satisfaction and contentment, but pleasure only brings greed, obsession and addiction. Pleasure was originally a mechanism devised to reward behaviour that aided survival (such as mating and eating), but addictive things like alcohol, smoking and drugs ruin your life and any chance at happiness instead of helping you survive.

The foolish run around to seek temporary pleasure while the wise seek permanent happiness.

Posted in Life & Happiness

Early Bird

Posted on by Jinavie

According to a proverb, the early bird gets the worm. This means that people who wake up early to start working, grabbing opportunities as early as possible will ultimately be more successful than the lazy people waking up later. But is this necessarily true?

To wake up early and get enough sleep to function, an early bird must naturally sleep earlier than night owls. However, this also means that early birds are less likely than night owls to socialise late into the night, meeting and having fun with less people. Unfortunately, this is one of the best ways to make important connections with other people – some of whom may one day be your superior or looking to hire you. It has been statistically proven that personal connections are more important than actual skills and diligence, with up to 80% of promotions being based on connections rather than how well the person works.

According to a certain study, people who visited bars regularly earned 10-14% more than non-drinkers, with even social drinkers earning 7% more than those who preferred to call it an early night. So if you wish to be successful, sleep late, wake up later and go out and party.

Posted in Psychology & Medicine

Korsakoff’s Syndrome

Posted on by Jinavie

It is a well-known fact that excessive drinking leads to a so-called “blackout”. This form of memory loss is common in normal people and cannot be seen as a major illness. However, there is another disease that can be caused by excessive drinking called Korsakoff’s syndrome. Strictly speaking, this is not caused by alcohol but due to a thiamine (vitamin B1) deficiency and is commonly found in alcoholics and malnourished patients (it has also been reported to be caused by mercury poisoning and after centipede bites in Japan).

The six characteristic symptoms of this syndrome are: anterograde (cannot form new memories) and retrograde (cannot remember old memories) amnesia, confabulation, lack of detail in conversation, lack of insight and apathy.

Korsakoff’s syndrome patients show a very peculiar behaviour. As stated before they suffer from both anterograde and retrograde amnesia so not only can they not remember the past but they cannot make new memories either. Ergo, the brain uses information from its surroundings and attempts to recreate the lost memories, the result being confabulation. Confabulation is essentially what happens when the brain tries to fill in blanks in memories with false information. Confabulation is seen in everyday life too with healthy people but in the case of Korsakoff’s patients the effects are significantly more profound. For example, if you ask a patient what she did yesterday, she may look at your horse-print tie and claim she was horse-riding. If you ask the same question an hour later without your tie and instead holding a book with a photo of a Ferris wheel on the cover, she’ll state that she was at the amusement park. As one of the leading causes of amnesia and confabulation, Korsakoff’s should be suspected in any alcoholic or very underweight patient who keeps changing their stories around. 

As previously explained, the disease is caused by thiamine deficiency – therefore, the treatment is administering thiamine. But if the syndrome has persisted for a long time, the brain injury may be permanent. Also, treating the underlying alcoholism and malnutrition is important. 

If the thiamine deficiency is prolonged, it may lead to another disease called Wernicke’s encephalopathy. This is known as Wernicke-Korsakoff’s syndrome and in addition to the above symptoms, the patient may also experience confusion, tremors, nystagmus, paralysis of eye muscles, ataxia, coma and can eventually lead to death. All because of a deficiency of a single vitamin.

Who said nutrition is not important?

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(NB: Dory from Finding Nemo is one of the most accurate portrayals of amnesia in films)

Posted in Science & Nature

From Cell To Birth: Growth

Posted on by Jinavie

After implantation, the embryo quickly grows from a ball of cells into what will be a fully-formed baby. However, it first needs a way to feed: the placenta.
It is an organ that actively takes nutrients and oxygen from the mother’s blood, exchanging it for the embryo’s waste products. It is extremely effective in keeping the fetus alive and protects it from infections or the mother’s immune system.
The blood is carried by the umbilical cord, which plugs into the belly button. This cord is the lifeline throughout term, and disrupting the blood supply will lead to permanent brain damage or even death.

In the first 10 weeks, the blastocyst develops into a very primitive disk-like object that shares no resemblance to a person. It keeps growing and differentiating at a rapid rate (almost doubling in size per week) until it forms an embryo that is more familiar, roughly about week 6. Interestingly, a human embryo looks almost identical to embryos of rabbits, chickens, turtles and fish, showing how all animals shared a common ancestor in the course of evolution. At this stage, the embryo has features such as gills, a tail and a fish-like appearance.

After 10 weeks, the embryo has grown to about 5~8cm (almost 10~20 times the size at week 6), and is now called a fetus. It begins to properly grow organs, and resembles a miniature baby with primitive features.
It continues to grow for the next 30 weeks, continuously relying on the mother for nutrition and life support.

Many different factors contribute to premature birth and IUGR (intrauterine growth restriction), which leads to the birth of a small baby. This may result in less developed organs (especially the lungs) and may affect the health of the newborn throughout its life. There are also many poisons known to harm the development of the embryo/fetus, such as alcohol, nicotine, cocaine, heroin and much more. These should be avoided from a few weeks before conception onwards (even after birth while breastfeeding).

By about 38 weeks, the lungs (the last organs to fully mature) are ready and the fetus is upside down. It is ready to leave the womb, and thus sends a signal to the mother, known as labour. This is when the arduous process of childbirth begins.

(Full series here: https://jineralknowledge.com/tag/arkrepro/?order=asc)

Posted in Psychology & Medicine

Beer Goggles

Posted on by Jinavie

There’s only one thing other than love that can make a person oversee another’s weaknesses and amplify their strengths – alcohol. The term beer goggles refers to this phenomenon, where a member of the opposite sex appears more attractive due to the influence of alcohol. This is because alcohol inhibits the cerebral cortex where higher order thinking occurs, reducing sexual inhibition and allowing primitive behaviour to surface.
Beer goggles can be utilised to increase the chances of succeeding in courtship if one knows how to manipulate it.

There is even an equation to calculate the strength of beer goggles, produced from actual scientific research and experiments. The equation is:

An = number of units of alcohol consumed
S = smokiness of the room (graded from 0-10, where 0 clear air; 10 extremely smoky)
L = luminance of ‘person of interest’ (candelas per square metre; typically 1 pitch black; 150 as seen in normal room lighting)
Vo = Snellen visual acuity (6/6 normal; 6/12 just meets driving standard)
d = distance from ‘person of interest’ (metres; 0.5 to 3 metres)

Ergo, the more you drink, the further you are from them, the smokier and darker it is and the worse your eyesight, the beer goggle index (ß) rises and the subject becomes more attractive, thus increasing the probability that you will approach that person.