Posted in Psychology & Medicine

Viscera: Thyroid

(Learn more about the organs of the human bodies in other posts in the Viscera series here: https://jineralknowledge.com/tag/viscera/?order=asc)

There lies a small, butterfly-shaped organ called the thyroid gland in your neck, just in front of your windpipe above the clavicles. The thyroid may not seem important given its small size, but it has the important function of controlling the body’s rate of metabolism. Metabolism is a group of chemical reactions your body relies on to function as a lifeform. Chemicals such as glucose are processed by various enzymes – biological catalysts that encourage chemical reactions – and converted in to fuel (such as ATP) that cells can use for numerous bodily functions. The thyroid produces the thyroid hormones, thyroxine and triiodothyronine, to fine-tune the rate at which these reactions occur.

image

To see the function of the thyroid gland, we can look at two types of diseases: hyperthyroidism and hypothyroidism.

In hyperthyroidism, the thyroid is overactive and produces too much thyroxine. This causes the body’s metabolic rate to speed up, causing increased heart rate, weight loss, sweating, tremors and sensitivity to heat. Depending on the cause, the eyes may be affected as well, causing them to protrude forwards, giving a rather scary appearance. This disease may happen for various reasons, but the most common cause is Grave’s disease, where antibodies lock on to receptors in the thyroid to stimulate thyroxine production, much like a stuck key on a keyboard.

image

Hypothyroidism is the direct opposite syndrome caused by an underactive thyroid. This causes a reduction in metabolic rate, leading to weight gain, tiredness (due to lack of energy), slow heart rate and cold intolerance. It can also be caused by an autoimmune disorder (called Hashimoto’s thyroiditis), or more commonly due to iodine deficiency, as the thyroid uses up iodine to produce thyroid hormones.

Both diseases may cause the thyroid to grow to an abnormal size, which is called goitre (seen as a large neck lump). The treatment is usually adjusting the total level of thyroid hormone produced by removing parts of or all of the thyroid, or replacing thyroid hormone if needed via medication.

image

Because the thyroid uses iodine to make hormones, thyroid diseases such as thyroid cancer can be treated using an interesting method. If you inject radioactive iodine into the patient, it will make its way to the thyroid gland, which actively collects the iodine from the blood. Overactive thyroid tissue (such as in Grave’s or thyroid cancer) take up iodine at a faster rate. The iodine then delivers a focussed dose of radiation to the thyroid, leaving the other tissues in the body unharmed. This method is used for both first-line treatment of hyperthyroidism and to clean-up remaining cancer cells after thyroid surgery.

image

Posted in Science & Nature

Wine Aging

One of the (many) defining features of a “great wine” is the aging of the wine. The complex chemical reactions between the wine’s sugars, acids and tannins can produce a much deeper, sophisticated aroma and taste that stays in the mouth for longer. For example, the tannins break down to give a softer mouthfeel. Acids and alcohols combine in the wine to form esters – chemical compounds that produce very unique smells. This also reduces the perceived acidic taste of the wine, making it less sour. The longer the wine has aged, the more of these chemical reactions occurs and the wine typically improves in quality.

Of course, the problem with wine of excellent quality is the price and the time required to age the wine. Is there any way to artificially “age” wine? The solution lies in something that sounds like science fiction: irradiating the wine.

If you expose a bottle of wine to radiation (about 500 rads) for an hour, it can greatly improve its maturity. In a simple experiment, blind-tasted sommeliers could not believe that the two glasses of wine – one before irradiation and one after – were exactly the same. In fact, they valued the irradiated wine at almost five times the market price of the original bottle. The reason for this is that radiation accelerates the esterification process of the acids in the wine, producing a much deeper and smoother taste.
There are also other experiments that have shown that magnetism, ultra-sonic waves and high-voltage electricity can all be used to artificially age wine.

Although radiation does not turn people into superheroes, it turns out it can for wine.

Posted in Science & Nature

Banana Equivalent Dose

No form of energy has been more feared or creatively explored in science fiction (e.g. Godzilla) as radiation, yet the layman tends to know little about the actual properties and effects of radiation. The word “radiation” is commonly associated with things like Chernobyl, mutation and cancer. However, most people only know that radiation is “bad” while not knowing exactly how and why it is dangerous. Radiation is essentially high-frequency light which can deliver a large dose of energy (just like how microwaves cook food and sunlight can burn paper when focussed through a magnifying glass). When this high-dose of energy passes through living organisms, it damages the DNA in cells, potentially causing irreparable damage. This can lead to mutation and disruption of cell division (which can lead to cancer) or cell death (which is why radiation is ironically used to kill cancer cells).

The more technical question is “how much” radiation is harmful. For example, how much more dangerous was the Chernobyl incident compared to an x-ray? Like many other things in science, radiation is measured using an internationally universal unit called the Sievert (Sv). The radiation received from standing next to the Chernobyl reactor core after meltdown was 50Sv, while a chest x-ray is 20μSv (1000μSv = 1mSv, 1000mSv = 1Sv). Therefore, the Chernobyl incident could be considered to be as strong as 2.5 million chest x-rays. Although there is great variation, it is considered that a dose of 400mSv can cause symptoms of radiation poisoning, while 4~8Sv of radiation will lead to certain death.

Fascinatingly, radiation is not an uncommon thing. Radiation is all around us, with an average person receiving about 10μSv of background radiation per day just by living on Earth. Ergo, two days of walking around gives you the same amount of radiation as a single chest x-ray. A CT scan gives out a significantly greater dose of radiation at about 7mSv (approximately 350 x-rays or a year’s worth of background radiation).

However, the Sievert is a unit that is difficult to understand. Thus, some scientists devised a clever, humorous equivalent unit called the banana equivalent dose (BED). Bananas contain a certain amount of radioactive isotopes (radioactive potassium), making them technically radioactive. A banana contains 0.1μSv of radiation. Ergo, a chest x-ray is the equivalent to eating 200 bananas, a CT scan is 70000 bananas, while the Chernobyl incident gave people nearby a dose of roughly 500 million bananas.

The banana equivalent dose is a rather useful (and hilarious) way of comparing the danger of radiation from different sources. The next time you go to hospital for an x-ray, just picture 200 bananas being shot through your chest.

Posted in Science & Nature

Nuclear Explosion

Nuclear weapons are quite possibly the most dangerous weapons mankind has ever developed. Through the use of nuclear fission, atoms are split to release the massive amounts of energy contained within, causing a gargantuan explosion. When a typical nuclear bomb detonates, energy is released in various forms: blast energy (40~50%), heat (30~50%), radiation (5%) and fallout (5~10%). The distribution of the energy varies according to the type of bomb (e.g. neutron bombs produce significantly more radiation than heat and blast energy).

The initial damage that follows a nuclear explosion is from the blast energy, much like a conventional weapon. The sheer amount of kinetic energy creates a shockwave that pulverises everything in its path, travelling at speeds over 1000km/h. In addition, the heat from the explosion, over ten million degrees celsius at one point, causes vaporisation of all matter within a certain radius, causing a massive release of gases, fuelling the shockwave from the expansion. In the case of the bomb that destroyed Hiroshima, all structures within 1.6km were vaporised and those within a 3.2km radius suffered moderate to severe damage. A modern nuclear weapon is at least tens of times more destructive and will affect a significantly larger area.

At the same time, thermal radiation spreads out in all directions much like sunlight. Thermal radiation travels far further than shockwaves and can cause severe burns and eye injuries (flash blindness) to people in the vicinity (if they are close enough, they will spontaneously combust or melt). Near ground zero (point of explosion), a firestorm may erupt from the sheer amount of heat energy, as observed as a fireball. 

Next comes the indirect effects.
Ionising radiation is produced when atoms are split and these have detrimental effects on living organisms. Not only are they responsible for mutations in the genome, leading to deformed offspring, sterility and cancer, but if there is sufficient radiation, a person will immediately die from acute radiation poisoning.
The same radiation, especially gamma rays, creates what is called an electromagnetic pulse (EMP). EMP is caught by metal objects and induces a high voltage surge, destroying unshielded electronic devices. Sometimes, nuclear bombs are detonated at very high altitudes so that only the EMP affects the ground, damaging enemy communications and destroying entire power grids.
Lastly, radioactive material rains from the sky for long periods of time, also known as fallout. Fallout causes continuous radiation damage in affected areas.

A nuclear bomb is truly a weapon of mass destruction as it utilises various forms of destruction to devastate all life forms within an area spanning several kilometres, even killing over the course of time in the form of radiation.

Posted in Science & Nature

Water Bear

A water bear, also called a tardigrade, is actually an insect and not a bear. The nickname is due to its slow, bear-like gait. It ranges in size from 0.1 to 1.5mm and resembles a short caterpillar with eight legs.
The reason for the water bear’s fame is its amazing survivability. In short, a water bear can live anywhere.

Water bears are capable of cryptobiosis. This can be seen as an extension of hibernation and it is an organism’s ability to lower its metabolism to near-death rates in order to survive a harsh environment. In this state, a water bear can survive for indefinite amounts of time.

Why is cryptobiosis useful? The answer can be found from the water bear’s natural habitats. The water bear is found on the highest point of the Himalayas, the deepest oceans, hot springs and virtually any location from the North Pole to the South Pole. It can survive temperatures from 151°C to minus 273°C, the intense pressures in deep seas and even vacuum states.
Furthermore, water bears can survive in space. A recent experiment by NASA on the International Space Station found that not only can they live in space, but they also mated and laid eggs that later hatched. They can even survive heavy doses of radiation and toxic chemicals.

Ergo, if a cockroach can survive a nuclear war, water bears can survive even if the Earth was split in two. If we took a leaf out of the water bear’s book and lead a slower life, could we live a longer and happier life?