Posted in Science & Nature

Virgin Birth

Although the concept of virgin birth (i.e. conception without intercourse) is common in many religions, there is no conclusive evidence of actual human virgin birth in recorded history. Except in one medical article written in 1874 by a Dr Capers.

In this article, Dr Capers describes a case study of a miraculous conception during the Battle of Raymond during the US Civil War. A soldier was shot in the testicles and the musket ball carried the non-musket ball (read: testicle) into the uterus of a girl working in a nearby field. The doctor attended to the girl who was shot and treated the wound in her abdomen. The bullet was not found.

Over the following nine months, the doctor realised the girl was pregnant, although she claimed to be a virgin. After nine months, a healthy boy was born. Stranger yet, the doctor realised the boy’s scrotum was unusually swollen and upon examination, found that he was carrying the musket ball that impregnated the girl in the first place. He thus concluded that the testicle that was carried by the musket ball was lodged inside her uterus and sperm leaked out. The soldier was eventually found and was told about this bizarre story and the two were married.

This case study has become a famous story told by doctors around the world. Unfortunately, it is completely false and the doctor who wrote the article admitted to faking it to amuse himself. Ergo, there are still no recorded cases of a virgin birth in humans.

The closest to a virgin birth that was recorded is a case study of a young woman who was performing oral sex on a man. She was found by her boyfriend during the act and the boyfriend stabbed her and her lover with a knife. The knife injured her oesophagus, causing the sperm in it to track down the abdomen and down to her reproductive organs. By a stroke of luck, an egg was misplaced during ovulation, causing it to drift into the abdomen instead of the fallopian tube (ectopic pregnancy), and met with the sperm. The egg was then fertilised and the girl presented to the hospital three months later with excruciating abdominal pain. The ectopic fetus was removed.

Posted in Science & Nature

Mother Horse

Female horses (mares) exhibit a very strange behaviour after they mate with a male. A mare will mate with every other male in the stable, almost immediately after mating with the first one. This strange post-coital promiscuity does not appear to make any sense from an evolutionary perspective, as one would think that pregnancy would lead to a decrease in libido so the mother can focus on caring for her embryo. However, this promiscuity is part of a strategy that helps protect the baby horses.

It is common behaviour in the animal kingdom for a male to kill a female’s young so that he can mate with her and produce babies with his own genetic material. This also happens in horses, where stallions engage in infanticide, kicking a foal to death if it is not his. For a mother horse, this is not only heartbreaking, but also a tremendous waste of the energy she put into pregnancy. So to protect her offspring and conserve energy, she ensures that no male knows who the father of her baby is. It has been shown that males who mated with a female who gave birth will not attack the foal, as there is a chance that it is his. Thus, a mother horse guarantees the protection of her child by prostituting herself to all of the males around.

Although the story of a mother willing to sacrifice everything, even her dignity, for the safety of her offspring may be inspiring, it has also been observed that if a mare cannot mate with all of the males in the stable, she will instead abort the pregnancy. For example, if a new horse is brought into the herd after the mare becomes pregnant, the mare senses the danger to her eventual foal and proceeds to abort it. In a study involving zebras, it was found that bringing in a new male made the foal’s chances of survival fall to less than 5 percent.

Posted in Psychology & Medicine

Pica

Occasionally, there are news stories about a man who eats steel or a girl who likes to eat plastic. Such a condition where the person develops an appetite for a non-food substance is called pica. Pica is more common than one would think. The most common cases are those of dirt, clay and chalk, with the disorder being much more prevalent in children or pregnant women. Although pica is officially a mental disorder (possibly related to OCD), it is possible that it is a neurological mechanism to cure a certain mineral deficiency. For example, patients with coeliac diseases or hookworm infections tend to be iron-deficient and the substances they eat tend to contain iron. It is unclear how the brain knows what “food” to eat to cure a disease, but there are many cases where people subconsciously consume foods that would improve their health. According to a study, between 8% and 65% of people have had a sudden urge for a very strange appetite. However, as substances commonly involved in pica (such as dirt and ice) are solids, they can damage the oesophagus and the digestive tract. Also, they may contain toxic chemicals which can cause poisonings, making pica a potentially dangerous condition.

Posted in History & Literature

Incubus

An incubus, much like a succubus, is a demon that visits in a dream or while a person is sleeping. An incubus is the male counterpart to the succubus and shares many of its characteristics, such as visiting a person to have sex with them (since it is male, it only attacks women). According to legends, a woman pregnant after having sex with an incubus gives birth to a stillborn or a deformed child. The legend of the incubus most likely arose to explain the hallucinations seen with sleep paralysis and a pregnancy out of wedlock or from a shameful relationship. During the Renaissance when the culture was less restrained around sex than the Middle ages, there was a rise in cases of young girls giving birth to stillborns without knowing who the father was, resulting in debates to whether an incubus could really impregnate a woman.

The most famous “child” of an incubus is Merlin from the King Arthur legends. Merlin’s mother was a woman of high class but gave birth to Merlin after being attacked by an incubus. She was afraid that Merlin would turn out to be an evil person so she took him to the church to cleanse his body. This left Merlin with only mysterious powers, allowing him to be one of the most famous wizards in fiction.

Posted in Psychology & Medicine

Couvade Syndrome

A patient comes to a doctor complaining of the following symptoms: “I can’t sleep because my teeth have been aching for the past few weeks. My head is killing me and whenever I wake up in the morning my stomach hurts and I feel nauseous and want to vomit. Sometimes I have no appetite and sometimes I crave a certain food. My breasts have gotten bigger and my stomach is bulging quite a bit.”
The patient has been married for three years and in a few months will have a beautiful daughter.
What is the diagnosis?

Most people would immediately say “Pregnancy!”. But there is one small detail that was left out: the patient is a man.
It is common sense that men cannot be pregnant. So what is this man suffering from?

Couvade syndrome is also known as sympathetic pregnancy. In other words, the husband subconsciously copies his wife’s pregnancy and suffer the same symptoms. This syndrome can be severe enough to cause labour pains, nosebleeds and even post-partum depression.
The cause has not been established, but it is likely to be psychosomatic, where psychological symptoms are expressed through physical symptoms, or due to changes in hormone levels.

Posted in Psychology & Medicine

Toxoplasmosis

There is a protozoan parasite called Toxoplasma gondii. This parasite infects many animals through an interesting route. 
The first victim is a mouse. An infected mouse loses its fear of cats, leading it to play fearlessly in front of one until it gets caught and eaten (was Jerry a mouse with toxoplasmosis?). It is unclear how it controls a more advanced animal’s brain, but thanks to this effect, Toxoplasma gondii can infect its intermediate host – a cat.
An infected cat starts excreting parasite eggs with its faeces. If a person forgets to wash their hands or eats food contaminated with cat faeces, they can be infected and become the final host for the parasite.

Usually, Toxoplasma gondii cannot overcome the healthy immune system, but it can infect those with a weaker immune system such as the elderly or pregnant women. Furthermore, it is part of the TORCH complex (toxoplasmosis, rubella, cytomegalovirus, herpes) – a group of infections that commonly cross over from the mother to the fetus in utero. Symptoms are normally flu-like, but if more severe it can cause dysfunction of the eyes, brain and other vital organs. Sometimes it lies dormant until the person’s immune system is weakened, whence it becomes active. Toxoplasmosis is also a possible cause of a miscarriage or infertility.

One fascinating symptom of toxoplasmosis is psychiatric disorders. Because Toxoplasma gondii can infiltrate the brain, it is known to cause depression or even schizophrenia. As cats are the most common intermediate host, cat owners are more susceptible to toxoplasmosis. Because of this, there is a theory that “crazy old cat ladies” are in fact toxoplasmosis patients.

Posted in Science & Nature

From Cell To Birth: Fertilisation

Once the sperm enters the vagina, the real battle begins. The vagina is highly acidic, an environment in which sperm can only survive 2~3 hours. It is crucial for the sperm to enter the uterus through the cervix, but only 1% of the 200~300 million sperm make it through.

Even within the uterus, they must brace harsh conditions as they travel against gravity. After about 5 hours of intense swimming, the sperm reach the top of the uterus. Here they face a choice: go left or go right. Half the sperm make the wrong choice and head down the eggless fallopian tube and ultimately die. The rest navigate their way through the maze of folds in the fallopian tube, often getting lost or sticking to the wall thinking that it is an egg.

About 200 sperm finally make it to the egg, which sits in the ampulla of the fallopian tube. But as always, there is competition even at this final moment. Only one sperm can win the race, and the fastest one will ultimately produce a new life.

When the first sperm touches the egg, a series of chemical reactions occur, essentially “priming” the sperm. This causes it to start the acrosome reaction, where it releases a hoard of enzymes from its head, digesting away the covering shell (zona pellucida) of the egg. It then becomes supercharged, using all of its energy to drive itself inwards until it reaches the oocyte within. As soon as this happens, the tail breaks off, and one final chemical reaction as the calcium level spikes occurs to release more enzymes that prevent the acrosome reaction in other sperm. It also solidifies the zona, forming an impenetrable shield to prevent other sperm coming in (polyspermy can lead to a failed pregnancy).

The calcium spike that causes the above cortical reaction also triggers the egg to divide, so that it reaches the most mature stage. The winning sperm can then combine its nucleus with the oocyte, forming the 46 chromosomes that will set the genetic basis of the new zygote (first stage of a baby).

To reach the egg, the sperm must travel over 20cm – beating its tail over 20,000 times. The probability that a certain sperm will fertilise the egg is 1 in 500,000,000.
Life starts under a near-zero probability condition.


(Full series here: https://jineralknowledge.com/tag/arkrepro/?order=asc)