Posted in Psychology & Medicine

Fried Rice Syndrome

Food poisoning is most often caused by the bacteria Staphylococcus, which produces a toxin that stays on food even when it is properly prepared. The body senses the toxin and promptly tries to rid itself of the toxins, resulting in heavy vomiting 1-2 hours after eating the spoiled food.

Many different germs can cause food poisoning, among which one of the most interesting is Bacillus cereus. B. cereus is found on many different foods, but it is commonly associated with a type of food poisoning called fried rice syndrome. It creates spores that can survive if food is not improperly cooked (as in not hot enough or cooked for long enough), as the temperatures are not high enough.

Unlike infections such as gastroenteritis where the bacteria are killed by heat during cooking, spores are quite resistant to short periods of reheating, such as microwaving. This means that if the spores were not killed when the rice was first cooked, it stays around even after refrigeration and reheating. The bacteria grow from the spore and start producing a toxin called cereulide. One to five hours later, the person who eats this tainted rice develops severe vomiting and nausea.

Fortunately, like most food poisonings, fried rice syndrome is easily treated with supportive management. The body does most of the work by decontaminating itself through vomiting. The important part is staying hydrated by keeping up with fluid loss. Most food poisoning cases resolve on their own within 24 (miserable) hours.

Posted in Science & Nature

Silver

Historically, silver has been associated with cleansing, healing, the moon and warding off evil. For example, it is said that some monsters such as werewolves would only die if it is shot by a silver bullet. The Greek goddess of hunting and the moon, Artemis, carries a silver bow. Although it is always seconded to gold when it comes to precious metals, silver is a fascinating metal.

It is the most reflective metal on Earth and has the highest conductivity for heat and electricity. It is ductile and malleable, making it a good choice of metal for making coins, jewellery and silverware (hence the name). Because of how reflective it is, it is also used in solar panels and special mirrors, such as those in telescopes.

Another useful characteristic of silver is its chemical reactivity. Thanks to this property, silver forms many different compounds with varying applications. Silver halides are photosensitive and turn dark when they are exposed to light. This is the basis of film photography, where the light shone on a film coated with silver halides leaves a photographic imprint. Silver oxides are sometimes used in batteries and silver/mercury alloys are used for dental fillings.

Silver also plays a role in medicine. Silver ions have been shown to inactivate bacteria such as E. coli, making silver nanoparticles a useful antiseptic that can be impregnated into different materials such as wound dressings. Silver nitrate sticks are used in emergency departments as applying it to a bleeding vessel in the nose will release nitric acid, which cauterises (burns off) the vessel to stop a nosebleed. In medieval Korea, silver spoons were used to test if a food has been poisoned with arsenic, as arsenic reacts with silver to form a black tarnish. If a person has too much silver build-up in their body, they can develop argyria (silver poisoning), which turns the skin an eerie bluish-grey colour.

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Posted in Science & Nature

Mandrake

The plant Mandragora officinarum, more commonly known as mandrake, is a plant that has interested people in various fields throughout history. Firstly, the root is split into two at the end, giving the uprooted plant the appearance of a human being. Secondly, it belongs to the nightshade family, containing plants such as the infamous deadly nightshade (belladonna), tobacco, Datura, petunia, tomatoes and potatoes. Like its relatives the belladonna and Datura, mandrakes contain alkaloids such as atropine, scopolamine and hyoscyamine. These substances are potent (and toxic) hallucinogenics and sedatives, which is why they have had various uses ranging from witchcraft to anaesthesia to murder through poisonings.

The shape of the mandrake and its hallucinogenic effects have given it notoriety. Legend goes that when a mandrake root is dug up, it shrieks with such terror that anyone who hears it will die – possibly referring to the toxicity of the alkaloids. Historical texts give detailed instructions on digging up mandrakes by tying a hungry dog to the root and making it pull the plant out of the ground when the owner is out of earshot and he lures the dog with food.

Other folklore suggest that mandrake only grow when the ground is inseminated by semen dripping from a hanged man. This folklore is likely fuelled by the mandrake’s human-like appearance. Ancient and medieval literature associates mandrake being used to make fertility agents and love potions(again, likely related to the hallucinatory, sedative effects). Mandrake is a common ingredient in magic rituals of various kinds, such as in Wiccan rituals.

Alkaloids extracted from mandrake have been used in medicine since the Middle Ages, where extracts were used to anaesthetise patients before surgery, as it has a sedating, hypnotic effect. Eye drops made from mandrake extract were used for hallucinations and mandrake syrups were used to aide sleep. In modern medicine, scopolamine is used in motion sickness patches and atropine is used to speed up the heart rate when it slows too much.

The extensive list of supposed and actual properties of mandrake has made it a popular plant in fiction as well and it can be found in countless works throughout time, such as works of Shakespeare, Sir Arthur Conan Doyle and J.K. Rowling.

Posted in Psychology & Medicine

Mithridatism

Mithridates VI, the King of Pontus (ancient Greek/Persian state located in modern day Turkey), had a paranoia that there were people who wanted to assassinate him through poison. This likely stemmed from his father being poisoned by his mother (reportedly), who favoured his brother over Mithridates as the heir to the throne. He noticed in his youth that the meals brought to him induced stomach pains. He connected the dots and deduced that his mother was trying to poison him slowly so that his brother would become the next king. He fled to the wilderness and devised a plan to protect himself. It is said that he began taking a concoction of various poisons in non-lethal doses every day, to develop an immunity to the most common poisons available during his time. This led to the idea of mithridatism – the gradual self-administration of non-lethal doses of poison to develop immunity. Ironically, Mithridates’ plan backfired eventually when he attempted suicide by poison after a massive defeat against Rome. He found that the poison had no effect on him and had to request his bodyguard to kill him by sword.

Mithridatism has been recorded or suspected in various times of history. Indian epics tell the story of the king Chandragupta Maurya – the first king to unite India – who selected a group of beautiful girls and raised them in the palace. He gave the order to administer small amounts of poison to these girls as they grew up, making them invulnerable to toxins. He called these girls vishakanyas (poison maiden) and believed that they could be used as assassins who could kill men through the act of sex.
There are suggestions that Rasputin was also a practitioner of mithridatism and that this was why he survived an assassination attempt involving poison, but there is not much evidence for this.
The practice of mithridatism is also mentioned in various fictions, such as The Count of Monte Cristo and The Princess Bride.

The concept of taking small doses of something to build up an immunity is still used in modern medicine. Desensitisation therapy is used to treat certain allergies, by exposing the body to small doses of the allergen. It is well-known that alcoholics and drug addicts required more substance to achieve the same effect as most people because they develop tolerance to it. There is some evidence that mithridatism is an effective way to build immunity to venomous snake bites.
However, not all poisonings can be avoided with mithridatism. Poisons such as cyanide pass through the system too quickly to create any tolerance, while heavy metals simply build up in the body to create a toxic effect after a history of exposure.

Posted in Psychology & Medicine

Belladonna

The belladonna flower has a name that means “beautiful lady” in Italian. However, its other common name has a completely different meaning – the deadly nightshade. Both names can be explained by the uses of the flower throughout history. The deadly nightshade (Atropa belladonna) is a small shrub with purple bell-shaped flowers and shiny black berries. All parts of the plant contain various toxins such as atropine, scopolamine and hyoscyamine. These alkaloid toxins are included in a group of chemicals called anticholinergics, because they act on cholinergic receptors on neurons, which are involved in activating the parasympathetic nervous system. As cholinergic receptors are widely utilised throughout the body, anticholinergic toxicity causes a wide range of symptoms.

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The main symptoms of anticholinergic toxicity are best remembered using the following mnemonic:

  • Hot as a hare (increased temperature – reduced temperature regulation)
  • Blind as a bat (blurred vision – dilated pupils)
  • Dry as a bone (dry skin, eyes and mouth – decreased secretions)
  • Red as a beet (flushing – dilation of blood vessels)
  • Mad as a hatter (hallucinations and agitation – neurological interaction)

The name deadly nightshade is obvious as severe toxicity leads to seizures, coma and death. The reason why the deadly nightshade is also called belladonna is that the diluted extract from the plant was used as an eye drop to dilate women’s pupils – a look considered beautiful then (nowadays the effect is used to examine the eye). The toxins extracted are used in other fields of medicine too. Although not used now, anticholinergics were used as an anaesthetic for surgery due to its neuropsychiatric effects. However, atropine is still used in the emergency setting to reverse bradycardia (excessively slow heart rate), as anticholinergics speed up the heart rate. This highlights the fundamental principle of medicine that “the dose makes the poison”. For the only difference between medicine and poison is the dose… and intent (Oscar G. Hernandez, MD).

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Posted in Science & Nature

Dihydrogen Monoxide

Many people know about the dangers of chemicals such as lead and dioxin, but there is lack of awareness of an even bigger killed chemical: dihydrogen monoxide. It is a colourless, odourless, tasteless chemical that is responsible for the death of hundreds of thousands of people around the world.

Most deaths caused by dihydrogen monoxide (DHMO) are by accidental inhalation, causing cerebral hypoxia. However, the dangers of DHMO do not end there. Its solid form can cause severe tissue damage after prolonged exposure, and both its gas and liquid forms can cause severe burns. It is possible to overdose on DHMO, with symptoms ranging from excessive diaphoresis and micturition, bloating, nausea, vomiting and body electrolyte imbalance such as hyponatraemia. For those who are dependent on it, withdrawal means certain death. DHMO has also been found in various types of tumours biopsied from terminal cancer patients.

Not only does DHMO have consequences on human health, it is also damaging for the environment. DHMO is the leading cause of the greenhouse effect (surpassing carbon dioxide), a key component of acid rain, accelerated corrosion and rusting of many metals and contributes to the erosion of natural landscapes. DHMO contamination is a real, global issue, with DHMO being detected in lakes, streams and reservoirs across the globe. DHMO has caused trillions of dollars of property damage in almost every country, especially in developing nations.

Despite the danger, DHMO is commonly found in the household, in the form of additives in food and drinks, cleaning products and even styrofoam. There are no regulation laws for DHMO and multi-national companies continue to dump waste DHMO into rivers and the ocean. It is astounding to see such a deadly chemical go unregulated.

If you have not caught on by now, dihydrogen monoxide’s chemical formula is H2O – also known as water. Technically speaking, there are no false statements in the above description. But even children know that water is not only (relatively) safe, but necessary for life. The report on “dihydrogen monoxide” originates from a 1997 science fair project by Nathan Zohner, who was 14 years old at the time. His project was titled “How Gullible Are We?” and involved presenting his report about “the dangers of DHMO” to fifty school students to see what their reaction would be. 43 students favoured banning it, 6 were undecided and only one recognised that DHMO was actually water. Even more surprising is that there are cases (such as in California in 2004), where city officials came close to banning the substance, falling for the hoax. This goes to show how gullible people can be in the face of what they do not know.

Posted in Psychology & Medicine

Sleeping Sickness

A woman travelling in Africa is bitten by what appears to be a mosquito. She swats the insect and keeps on going about her journey. The next week, she finds that she has a small nodule where she was bit. She is also feeling slightly unwell, with fever and fatigue. Over the following two weeks, her fever worsens (coming and going intermittently) and she notices large lumps along the back of her neck. By this stage, she is experiencing muscle and joint pain as well. After returning home from her trip, she finds that her symptoms have not resolved. On top of her fever and pains, she begins experiencing headaches, mood swings, lethargy, confusion, clumsiness, delayed response to pain, sleepiness during the day and insomnia at night. She begins to worry that something is wrong, but she believes that it is a bad flu and does not see a doctor. Her symptoms worsen with time (sleeping up to 15 hours a day), until one day, she falls asleep and does not wake up. She is taken to a hospital, where it is discovered she is in a coma. She dies within a week.

This is the typical presentation of sleeping sickness, also known as human African trypanosomiasis. It is an infectious disease caused by a protozoan parasite called Trypanosoma brucei (comes in two types: T. brucei rhodesiense (East African type) and T. brucei gambiense (West African type)), which is transmitted by tsetse flies – a bloodsucking fly endemic to sub-Saharan Africa (there are also case reports of sexual transmission between people). When infected, the parasite rapidly proliferates in the patient’s bloodstream. It is not detected by the host immune system, thanks to a surface protein called VSG. This allows it to spread through the patient swiftly and silently via the circulatory and lymphatic systems. The early symptoms (intermittent fever, rash, lymph node enlargement), typically presenting about a week or two after infection, are due to the parasite spreading through the blood and lymph. As the infection spreads, the parasites begin to invade the central nervous system (although in the West African type of the disease, patients often die from the toxic effects of the parasite replicating in the blood before they reach this stage).

As the infection spreads through the CNS, it causes the neurological symptoms described in the case. The sleepiness (from where the disease gets its name from) worsens as the disease progresses, with patients finding it difficult to wake up in the morning, even sleeping for over 20 hours. The sleepiness is caused by a chemical called tryptophol, which is produced by the parasite. Essentially, the neurological symptoms appear as if the person’s brain is slowing down, until they fall into a coma, resulting in death without treatment (usually within 2~3 years since the infection).

Sleeping sickness is invariably fatal unless treated early. Once the patient reaches the second stage (neurological phase), treatment becomes very difficult. The current first line treatment is a drug called melarsoprol, which is a form of arsenic. Because of its toxic nature, it is extremely dangerous and there is around an 8% chance of the patient dying from side effects. Fortunately, there are less dangerous and more effective treatments such as eflornithine (which only works for the West African type) being developed.

Posted in History & Literature

Zodiac: Sagittarius

Sagittarius is the Zodiac sign for those born between November 22 and December 21. The symbol for Sagittarius is centaur (half-man, half-horse) with a bow and arrow.

The model for Sagittarius is the wisest and most intelligent centaur, Chiron. Although most centaurs are known to be aggressive beasts only interested in women and alcohol, Chiron was different in that he was culture and civilised. He was interested in gathering knowledge and learning philosophy, especially medical knowledge. Chiron is also famous for being the teacher and master of many famous heroes and gods. Among his students are: the god of medicine, Asclepius; the Trojan War hero, Achilles; leader of the Argonauts, Jason; and the famous hero, Hercules. One day, Hercules ended up in a fight with some centaurs, which resulted in a bloody battle. Hercules used arrows coated with the poison of the Hydra (which he obtained during his twelve labours), swiftly killing many centaurs. Chiron saw this battle and galloped there to try and stop everyone from hurting each other. But Hercules did not see his master and accidentally shot him with a poison arrow. Although Chiron was given the gift of immortality by the gods, the Hydra’s poison still caused excruciating pain. Even though he was one of the best medical professions of his time, he could not alleviate the pain and begged Zeus to put him out of his misery. Zeus accepted this and raised him into the heavens to become a constellation as a sign of respect.

(Part of the Zodiac series: https://jineralknowledge.com/tag/zodiacs/?order=asc)

Posted in History & Literature

Zodiac: Scorpio

Scorpio is the Zodiac sign for those born between October 22 and November 21. The symbol for Scorpio is a gigantic scorpion.

The model for Scorpio is the scorpion that killed Orion. Orion was a great hunter. He always boasted that there was not a single animal that he could not kill and would kill every beast he saw in the forest. Many gods and goddesses were not pleased with his narcissism, but among them Artemis, the goddess of hunting, particularly disliked him. She was worried that he would kill every animal on Earth, threatening the ecosystem. So she summoned a giant scorpion and commanded it to kill him. The scorpion proceeded to swiftly sneak up to Orion and stung him with a deadly poison, killing him instantly. Thus, the great hunter Orion fell shamefully. Both Orion and the scorpion were lifted into the heavens and became constellation. This is why when the Scorpio constellation rises in the night sky, the Orion constellation hurriedly falls to the west, scared that he might be attacked once more.

(Part of the Zodiac series: https://jineralknowledge.com/tag/zodiacs/?order=asc)

Posted in Psychology & Medicine

Pica

Occasionally, there are news stories about a man who eats steel or a girl who likes to eat plastic. Such a condition where the person develops an appetite for a non-food substance is called pica. Pica is more common than one would think. The most common cases are those of dirt, clay and chalk, with the disorder being much more prevalent in children or pregnant women. Although pica is officially a mental disorder (possibly related to OCD), it is possible that it is a neurological mechanism to cure a certain mineral deficiency. For example, patients with coeliac diseases or hookworm infections tend to be iron-deficient and the substances they eat tend to contain iron. It is unclear how the brain knows what “food” to eat to cure a disease, but there are many cases where people subconsciously consume foods that would improve their health. According to a study, between 8% and 65% of people have had a sudden urge for a very strange appetite. However, as substances commonly involved in pica (such as dirt and ice) are solids, they can damage the oesophagus and the digestive tract. Also, they may contain toxic chemicals which can cause poisonings, making pica a potentially dangerous condition.