Author: Jinavie

Posted in Psychology & Medicine

Psychopath

Posted on by Jinavie

A common character found in psychological thrillers are those who seem to have no regard for the well-being of others, disobey social rules and act violently for seemingly no reason. They show no remorse or empathy and can be very intelligent, charming and high-functioning (although not typically). We describe these people as psychopaths, or sometimes sociopaths. To over-simplify it, a psychopath essentially has no moral conscience and do not believe in the social contract.

The terms psychopath and sociopath are often used interchangeably, but in modern psychiatry, they both fall under the diagnosis of antisocial personality disorder (ASPD). ASPD patients tend to have a long history of criminal charges, often relating to violence, chronic lying and fraud, drug use and other law-breaking actions. These characteristics may show from early childhood, with the typical psychopathic child being described as one murdering animals and being violent towards other kids. These children are often diagnosed with another disorder called conduct disorder.

Psychopaths are very popular in movies and TV shows due to their unpredictable nature, wanton violence and maniacal behaviour inflicting terror into the audience’s hearts. After all, who wouldn’t be afraid of a remorseless killer who finds enjoyment from others’ suffering? Unfortunately, many movies distort the image of the psychopath and blend in various other mental health disorders such as psychosis into the character. Sometimes psychopaths are even sensationalised, being described as an antihero.

It is true that many serial killers turn out to be psychopaths, but physical violence is not necessarily a feature of all psychopaths. A subset of “successful” psychopaths differentiate themselves by being less physically violent, appear to follow the social norm and succeed in challenging fields such as business, finances, law or even medicine. However, they will also have a pervasive disregard for others and will only care about having their way. Their lack of empathy allows them to act immorally, stabbing people in the back and lying, cheating and manipulating their way to the top. It is not some sick sexual perversion or power trips that motivate psychopaths, but impulsivity, egocentricity and gratification. To psychopaths, the aim of the game is to win, no matter the cost.

This makes you wonder. How many people around you are secretly a psychopath – one who would take advantage of you without a shred of guilt? How many people around you hide behind the mask of sanity?

(NB: Just putting it out there, Sherlock Holmes is neither a psychopath nor a sociopath. If anything he probably has an autism spectrum disorder like Asperger’s syndrome.)

Posted in Psychology & Medicine

Mithridatism

Posted on by Jinavie

Mithridates VI, the King of Pontus (ancient Greek/Persian state located in modern day Turkey), had a paranoia that there were people who wanted to assassinate him through poison. This likely stemmed from his father being poisoned by his mother (reportedly), who favoured his brother over Mithridates as the heir to the throne. He noticed in his youth that the meals brought to him induced stomach pains. He connected the dots and deduced that his mother was trying to poison him slowly so that his brother would become the next king. He fled to the wilderness and devised a plan to protect himself. It is said that he began taking a concoction of various poisons in non-lethal doses every day, to develop an immunity to the most common poisons available during his time. This led to the idea of mithridatism – the gradual self-administration of non-lethal doses of poison to develop immunity. Ironically, Mithridates’ plan backfired eventually when he attempted suicide by poison after a massive defeat against Rome. He found that the poison had no effect on him and had to request his bodyguard to kill him by sword.

Mithridatism has been recorded or suspected in various times of history. Indian epics tell the story of the king Chandragupta Maurya – the first king to unite India – who selected a group of beautiful girls and raised them in the palace. He gave the order to administer small amounts of poison to these girls as they grew up, making them invulnerable to toxins. He called these girls vishakanyas (poison maiden) and believed that they could be used as assassins who could kill men through the act of sex.
There are suggestions that Rasputin was also a practitioner of mithridatism and that this was why he survived an assassination attempt involving poison, but there is not much evidence for this.
The practice of mithridatism is also mentioned in various fictions, such as The Count of Monte Cristo and The Princess Bride.

The concept of taking small doses of something to build up an immunity is still used in modern medicine. Desensitisation therapy is used to treat certain allergies, by exposing the body to small doses of the allergen. It is well-known that alcoholics and drug addicts required more substance to achieve the same effect as most people because they develop tolerance to it. There is some evidence that mithridatism is an effective way to build immunity to venomous snake bites.
However, not all poisonings can be avoided with mithridatism. Poisons such as cyanide pass through the system too quickly to create any tolerance, while heavy metals simply build up in the body to create a toxic effect after a history of exposure.

Posted in Life & Happiness

The Joy Of Connection

Posted on by Jinavie

What is the commonality of the following? New parents holding their newborn baby, a young couple in love staring into each other’s eyes, catching up with an old friend and a hug. The obvious answer is that they are moments of happiness. But the real answer that lies beyond that is that they are all about connection. Human beings are social creatures and we are hardwired to like connecting with others. In the primitive days, not being connected to your tribemates meant a lower chance of survival. Over the years, we have evolved to the point where human connection is one of the greatest joys we can experience. Many things people may associate with “joy” such as money, sex and winning result in a flood of dopamine in the brain. Dopamine is great, it gives us a rush and acts as a reward system, motivating us to do more of the behaviour as it will likely result in more food or mates. However, dopamine quickly wears off and you need another “hit” to replicate the effects. The happiness produced by connection is based on a different neurotransmitter called oxytocin, which is produced en masse in events like physical contact (e.g. hug) and during childbirth. Oxytocin acts different to dopamine in that it sets up a “circuit” that is associated with a memory. If you recall a memory – either consciously or when you meet a stimulus such as a certain smell that reminds you of it – the oxytocin circuit fires up and gives you a dose of happiness. Thus, oxytocin is sustainable, true happiness.

Of course, the corollary to this is that the greatest suffering we can experience is the feeling of disconnection. Breaking up with your other half, being rejected, a dear friend moving far away, the death of a loved one… These events make us feel as if a piece of heartstring snapped, leaving a scar that aches for a long while. In prison, one of the harshest punishments is solitary confinement, where the inmate has no contact with any other human being for a set time. A characteristic of borderline personality disorder is emotional instability and impulsive decisions. A major trigger for this is the feeling of abandonment or the fear of rejection. Borderline patients tend to misinterpret a person through black-and-white thinking, conclude they must hate them, feel rejected and may go on to harm themselves or even attempt suicide. There is also some anecdotal evidence saying that babies who are brought up in institutions without a parent figure to truly connect to are more likely to develop personality and mental disorders, with an increased risk of death in infancy. To not be connected to anyone is true suffering.

So if you are still on the pursuit of happiness, go out there and connect. Whether it be the excitement of getting to know a new person or the rekindling of an old friendship, connection is the ultimate happiness.

(Image source: Puuung http://www.grafolio.com/puuung1)

Posted in Science & Nature

Pigeonhole Principle

Posted on by Jinavie

If I have three gloves, there must be at least either two left gloves or two right gloves. It is impossible to have one left glove, one right glove and a third glove that is neither left nor right (usually). This logic is called the pigeonhole principle. It is named because of the logic that if you have n pigeons and m pigeonholes where n > m (e.g. 10 pigeons in 9 holes), then at least one pigeonhole must contain more than one pigeon. This is because the biggest spread of the pigeons is putting at least one in each box, but as n > m, there is a pigeon left over and it must go in a box with another pigeon. The pigeonhole principle seems like a basic counting principle, but its implications are quite interesting.

For example, let’s say that your sock drawer is very unorganised and has a mix of black and white socks. What is the minimum number of socks you need to pick out before you get two of the same colour? The pigeonhole principle dictates that when n > m, each “slot” must be filled with more than one item. Here, the slot is colour. As there are two colours (m = 2), you only have to pick three socks out to have a matching pair (n = 3, 3 > 2).

The pigeonhole principle allows us to make seemingly impossible conjectures, such as the fact that a person living in London will have the exact number of hairs on their head as at least one other person living in London. An average human head has about 150,000 hairs and it would be a safe assumption to say that no one would have more than a million hairs on their head (m = 1,000,000). The population of London far exceeds a million (n > 1,000,000), therefore, there must at least two people living in London with the exact same amount of hair on their head. Similarly, if you are in a room with 366 other people, you are guaranteed to share a birthday with at least one person.

Posted in Psychology & Medicine

Silphium

Posted on by Jinavie

Although sex was devised by Mother Nature to promote procreation, humans have been trying to separate the baby-making aspect of sex from the pure carnal pleasure it gives for a very long time. The Romans are known to have used a fennel-like herb called the silphium as a form of birth control. They discovered that the leaves of this plant could be ground up and made into a resin pill, which seemed to reduce the likelihood of women becoming pregnant. The Roman scholar Pliny the Elder recorded that one could use the resin as a pill or pessary to promote menstrual discharge, suggesting pregnancy has not occurred.

News of this medicine spread throughout the empire and there was massive demand for it. The plant grew exclusively on a narrow coastal area in present-day Libya and was impossible to cultivate. This meant settlements in this area could trade the plant at a very high price. It is said silphium was “worth its weight in denarii (silver coins)”. Its economic importance is signified in coins from Cyrene (an ancient North African city where silphium was produced) depict the silphium plant or seed. In fact, one theory of the origin of the heart symbol is the shape of the silphium seed pod. Overharvesting of the plant, the fact that it could not be cultivated and other factors such as changing environments and overgrazing ultimately led to the extinction of this plant and scholars still debate the exact identity of the plant.

Although there are records that indicate silphium was used as a contraceptive and abortifacent (substance that induces abortion), it is unclear as to how effective it was. Related plants such as wild carrots have shown to have abortifacent properties in some studies and there certainly are a vast list of plants that could potentially harm or terminate a pregnancy. Regardless of the potency, the heavy trade of the plant and its intended use points towards the fact that the concept of contraception is not new to human civilisations. It is interesting to think that we are the only species to actively want to reduce the risk of making a baby during sex, which is the original purpose of sex.

Posted in History & Literature

Martini

Posted on by Jinavie

A martini is a classic cocktail made from 3~4 parts gin and 1 part dry vermouth. It is then stirred in a mixing glass with ice cubes, strained then garnished with a green olive or a twist of lemon peel. It is most famous for being the drink of choice of James Bond – the most famous spy in the fictional world. Bond frequently orders a vodka martini (vodka instead of gin) and is famous for asking it to be “shaken, not stirred”.

The reason for his preference has never been given in the novels, but that did not stop Bond enthusiasts, martini connoisseurs and even scientists from investigating why Bond may have preferred a shaken martini as opposed to a stirred one.

When you shake a drink with ice, it becomes colder than when it is stirred for the same amount of time. This may be the main reason Bond liked a shaken martini (also called a Bradford), as a martini is typically served as cold as possible.

However, shaking a cocktail has some consequences. The vigorous shaking will introduce more air into the cocktail (“bruising” the drink), which makes it taste sharper and more bitter. The bubbles also makes the drink cloudier and have a different texture. Furthermore, shaking causes the ice to chip (as opposed to the much gentler stirring), which serves to make the drink cloudier and more diluted. Therefore, the shaking essentially makes the drink weaker.

An alternative theory as to why Bond asked for his martini to be shaken is that vodka was often made from potato more than grain prior to the 1960s. Potato vodka has an oilier texture and shaking helps disperse the oiliness and improve the taste.

A biochemical analysis of stirred versus shaken martinis reveal that shaking causes more hydrogen peroxide to break down, meaning a shaken martini leaves half the peroxide left in a stirred martini. The reduced hydrogen peroxide content results in more antioxidants, which has health benefits such as reducing the risk of cardiovascular disease, cataracts and stroke.

Posted in Science & Nature

Millions And Billions

Posted on by Jinavie

Have you ever stopped and pondered what a million actually is? Sure, you might easily pass it off as the number 1,000,000, or a thousand thousands, but have you really tried to get your head around how big a number that is? For example, you may be able to visualise a hundred people, a thousand people or even tens of thousands of people in your head, but it is very hard to visualise an image of a million people.

Now consider this. When was a million seconds ago? You know a second is very short and a million is a very large number. But it is difficult to put the two together. Make a guess. Last year? Two months ago? Surprisingly, the answer is only a week and a half ago (11.6 days).
Then what about a billion seconds? A billion is a thousand million so you might think it is easy to just add some zeroes, but a billion seconds is 31.7 years ago. Just by changing one syllable, or adding three zeroes, we went from a scale of weeks to years. If we go one step further to a trillion seconds, you leap back in time 31,700 years. You can probably remember what happened a million seconds ago, you might not have even been born a billion seconds ago and our ancestors were still hunter-gatherers roaming Europe a trillion seconds ago. That is how mind-blowing the scale of large numbers can be.

Now let’s look at some other things to really understand how big a million and a billion can be. A million dollars (USD) could buy you a luxury house, a manufacturing line, a 41-acre island in Belize or over 200 years’ worth of coffee (if you drank two cups a day). A million dollars in $1 bills would weigh 1000kg and stack to 30 stories high. A billion dollars – even if you were to convert it into $100 bills – would weigh 10 tonnes, almost as heavy as the truck that would carry it.

The pitter-patter of raindrops on your face feels nice, but a million drops of water weighs 50kg and would break your neck. A billion red helium balloons would have enough lift to carry 14,000 tonnes – enough to lift a hundred small, two-storey houses up into the air. A million grains of rice will feed a person for almost two months, while a billion ants would weigh twice a standard car (3 tonnes total).

Related image

(You should definitely check out Hank Green’s take on “a million seconds”, because everything is better if Hank Green is ranting about it! http://www.youtube.com/watch?v=cJ7A0yTDiqQ)

Posted in Life & Happiness

The Perfect Toast

Posted on by Jinavie

Toast is one of those simple meals that anyone can make. Bread goes in, toast comes out. But some scientists decided to embark on a quest for the “perfect” toast. After spending a week toasting and tasting over two thousand slices of toast, the scientists came up with some figures.

The perfect toast should be:

  • 14mm thick
  • Made from pale-seeded loaf of bread taken from a fridge at 3°C
  • Cooked in a 900-watt toaster set to 5 out of 6 power
  • Cooked at a temperature of 154°C evenly from both sides
  • Cooked for exactly 3 minutes and 36 seconds (216 seconds)
  • Transferred gently to a plate that is pre-warmed to 45°C
  • Immediately slathered with 68.2mg per square centimetre of butter
  • Sliced once diagonally

The result of this formula is a perfectly golden-brown toast of 12:1 exterior to interior crispiness, with the “ultimate balance of external crunch and internal softness”.

Posted in Science & Nature

HeLa

Posted on by Jinavie

In February 1951, a woman named Henrietta Lacks was diagnosed with cervical cancer. The cancer was aggressive and her health quickly deteriorated, until her ultimate demise in October 1951. Although Henrietta Lacks passed away on that day, not all of her was dead. A scientist named George Otto Gey succeeded in culturing (growing on a petri dish) the biopsied cervical cancer cells, provided by Lacks’ physician. He discovered that this lineage of cells could keep dividing and growing without stopping. In the human body, cells will eventually reach a limit of dividing and be destroyed. The cells from Henrietta Lacks, however, were immortal. Gey named this cell line HeLa, taking the first two letters of Lacks’ first and last names.

The HeLa cell line (and all other immortal cell lines since) have proven very useful in research as they give an infinite supply of identical cells, giving scientists a model template they can experiment on. The immortality of the HeLa cells is such that 60 years later, scientists are still using cells from that lineage – cells virtually identical to the cells taken from Henrietta Lacks (save for random mutations that happen in any cells). The cells are so well-adapted to unlimited growth that they are sometimes considered a laboratory “weed”, because it can easily invade another cell culture and completely take it over. One biologist even went as far as claiming that HeLa cells were no longer human, but instead a new species. He supported his claim with the fact that HeLa cells are self-sufficient and can reproduce on its own, and that it has a different genome (even chromosome numbers) to human cells due to the nature of cervical cancer.

The main issue with HeLa cells is the ethics behind it. At no point did Lacks or her family give permission to the doctor for him to donate her cells for research. Since her death, the cells were not only used for the purpose of pure research, but also commercialised. Unfortunately, medical ethics was not well-established at the time and asking the patient’s consent for such things was not common. The two major sides in this debate would be the unethical act of taking human tissue and using it without consent, versus the potential benefit it brings. For example, HeLa cells were used by Jonas Salk for his research that led to the development of the polio vaccine. It may be a stretch, but if those cells were not taken from Lacks, the development of the polio vaccine may have been delayed and countless more people would have suffered from a lifelong crippling illness. This is the great question in medical ethics: how much of an individual’s human rights can we afford to sacrifice for the needs of the many? Do the needs of the many really outweigh the needs of the few, or the one?

Posted in Psychology & Medicine

Memories

Posted on by Jinavie

When you remember a scene from the past, you are not remembering the past. You are remembering a memory of the past. Your brain works in a very funny way where it does not record memories like film. Instead, it seems to remember things as a collage. Everytime you recall a memory – whether it be a happy memory of your first love, or a sad memory of lost love – your brain recalls your last recollection of the event. Simply put, every time you “remember” something, you are merely remembering the latest memory of the event. Each time you replay an event in your mind, it is rewriting a version of the memory over itself.

This means that the more you dwell on a memory, the more it is distorted. You romanticise the good parts and dramaticise the bad parts. The memory is ultimately warped beyond the point of telling the true story. Instead, it becomes something akin to a movie script or a fairy tale. But if it truly is a memory you deem special and hold dear, then maybe it isn’t too bad keeping a romanticised, “perfect” version of it somewhere in your heart to look back on every now and then.